Leinster have confirmed that Jamison Gibson-Park is not included in the squad for their opening United Rugby Championship match against the Johannesburg Lions at Ellis Park.
The Ireland international was sidelined following a minor groin injury sustained while starting two of the summer internationals against Australia and New Zealand.
Gibson-Park's absence adds to a growing list of injuries affecting Leo Cullen's side, which already includes Cormac Foley, Jordan Larmour, Diarmuid Mangan and James Culhane among those unavailable for selection.
Andrew Porter and Tommy O'Brien may feature on Saturday after both returned to full training, though Porter missed the summer Tests due to a calf injury while O'Brien was affected by a groin issue.
Joey Carbery has also increased his training intensity as he seeks to clear an anterior cruciate ligament injury sustained during his time at Bordeaux-Begles before rejoining the province over the summer.
No further updates were provided regarding Jack Boyle, RG Snyman, Caelan Doris and Paddy McCarthy, whose current fitness status remains unconfirmed.
The confirmed exclusion of Gibson-Park marks a significant blow to Leinster's attacking options for their home opener in the United Rugby Championship.