Sean Jansen has been excluded from Ireland's upcoming international engagements following a knee injury sustained during Friday's match in Dublin.
The forward was forced to leave the field early in the 42-12 victory over Argentina on November 8th and will now focus on rehabilitation at Connacht.
This development removes one of head coach Andy Farrell's primary options for the back row, compounding existing squad limitations.
Ireland are scheduled to face Fiji 'A' in Cork on November 20th before travelling to Twickenham for a final fixture against South Africa on November 21st.
Squad selections for the latter match remain fluid as captain Michael Sheehan undergoes twelve-day return-to-play protocols ahead of the Bok encounter.
Caelan Doris and Jack Conan continue to be unavailable due to their own injuries, further restricting Farrell's choices at number eight.
Tom Ahern, Ethan McIlroy and Michael Milne have all been confirmed out for the XV game against Fiji 'A'.
Fineen Wycherley, Todd Lawlor and Jeremy Loughman have been called up to fill gaps in the squad.
Uncapped Ulster forward David McCann has joined the selection, while Gus McCarthy is included to bolster options at hooker.
Centre Bundee Aki, who withdrew from the Argentina game due to illness, is expected to resume full training by Tuesday.
McCann and McCarthy were initially named for the Cork fixture but may be adjusted as protocols dictate.
No further details on specific return dates have been provided beyond the current injury status.
The squad will travel to Twickenham after completing their preparation in Derry City and Strabane District Council area facilities.
Official confirmation comes from the Irish Rugby Football Union regarding Jansen's exclusion.
Rehabilitation progress remains the primary focus for the forward during his time away from international duty.