Ireland defeated South Africa by a margin of twenty-three points in the opening WXV Global Series match played at Cape Town on Saturday.
The Irish squad recorded six tries to secure their first triumph during a tour of the Springboks' home territory.
This contest followed a previous encounter between the two nations in 2006, when Ireland won that Women's Rugby World Cup fixture in Canada by thirty-seven points to nil.
South Africa mounted a spirited response throughout the match, with number eight Aseza Hele scoring one of their most effective tries after penetrating the Irish defensive line.
Erin King received a sin-bin for a high tackle early in the first half, which impacted Ireland's initial momentum.
The contest featured six tries shared between both sides during an engaging opening period before Dublin took control.
Irish fly-half Dannah O'Brien demonstrated decisive kicking accuracy from the tee to separate the teams after the break.
Ireland will seek a third consecutive victory in their WXV campaign when they face South Africa again on 31 October at 13:00 GMT.
The visitors had previously lost their opening WXV game against the United States before overcoming Japan in Dublin last month.