Rhun ap Iorwerth of Plaid Cymru, John Swinney of the SNP and Michelle O'Neill of Sinn Féin are set to meet in Cardiff next month.
This gathering marks the initial face-to-face encounter between these nationalist leaders since Rhun ap Iorwerth took office in May.
All three first ministers have expressed a desire for their nations to exit the United Kingdom, a position unique among devolved administrations since the start of devolution.
While the political objectives align on the ultimate goal, specific demands differ regarding immediate action.
John Swinney and Michelle O'Neill are actively discussing the possibility of holding referendums in their respective regions.
In contrast, Rhun ap Iorwerth has stated that pursuing a referendum at this stage is not currently viable for Wales.
The meeting will also address how the three administrations can collaborate more effectively on shared challenges.
Michelle O'Neill serves as deputy first minister in Northern Ireland alongside her counterpart, with both holding equal constitutional powers.
Emma Little-Pengelly of the Democratic Unionist Party holds the position of deputy first minister in Belfast.
Political dynamics vary significantly between the three nations, particularly concerning internal governance structures.
Welsh officials are simultaneously campaigning for additional legislative authority to be granted to Cardiff.
These proposed powers would extend to areas such as policing and youth justice systems.
Rhun ap Iorwerth's party has maintained a long-standing campaign to reform the Barnett funding formula, arguing it places Wales at a disadvantage compared to other nations.
John Swinney's administration benefits substantially from the current financial arrangement.
Andy Burnham appeared to suggest a second Scottish referendum could occur if public backing were evident during recent parliamentary questions.
Prior to assuming his role as prime minister, Andy Burnham advocated for changes to the funding model.
However, during his recent trip to Wales, he downplayed the likelihood of such reforms being implemented soon.
The three leaders will discuss strategies to strengthen their collective position before meeting with the prime minister.