The attacker rammed his vehicle into people in Beit Shean, killing a man and injuring a teenage boy. He then drove onto a highway near Afula, fatally stabbing a woman and injuring another person.
The assailant was shot by police in Afula and taken to hospital in a stable condition. Authorities identified him as a 34-year-old Palestinian from Qabatiya who had used his employer's vehicle.
Israeli military forces launched a search operation in Qabatiya, including a raid on the attacker's residence. The military said it was targeting terrorist infrastructure and preparing to demolish the home.