A crash occurred on the Derrylin Road near Enniskillen at about 19:00 GMT on Friday evening. A Bus Éireann Expressway Route 30 service and a Ford Kuga were involved in the incident.
Two men in the car were pronounced dead at the scene. The driver and passengers of the bus were not reported to have sustained injuries. The Northern Ireland Ambulance Service dispatched two rapid response paramedics, two emergency crews, and an ambulance officer to the location.
The Derrylin Road remained closed overnight before reopening on Saturday morning. Bus Éireann confirmed its involvement in the crash and stated that passenger, staff, and public safety are paramount. The Police Service of Northern Ireland continues to investigate and has appealed for witnesses.