Ulster have selected five of their summer acquisitions to start against Edinburgh at the Affidea Stadium on Friday evening.
Ireland wing Robert Baloucoune returns to the starting line-up after spending time in Ireland's training camp during the break.
Last season's top try-scorer Zac Ward is included among the substitutes for the match.
Both players were part of Ireland's squad over the summer period.
Forward Eduardo Bello, Eli Snyman, Ben Donnell and Martin Moloney are named in the opening eleven alongside new recruit Jamie Benson in the backs.
Michael Lowry is appointed captain for the fixture.
James McNabney starts at number eight following his absence throughout last campaign due to a knee injury.
The Argentine debutant Bello joins Eric O'Sullivan and James McCormick in the front row, while Snyman and Donnell occupy the second row positions.
Former Exeter Chiefs forward Martin Moloney makes his competitive appearance at open-side flanker with McCann starting at blind-side.
Conor McKee and Jack Murphy form the half-back pair, supported by ex-Harlequins player Jamie Benson and Ben Carson in midfield.
Arenzana-King scored four tries in Ulster's pre-season encounters against Edinburgh and Ospreys.
The starting eleven forms part of a total of eight players in the matchday squad set to make their competitive debuts for the Irish province.