Wes Streeting has resigned as the United Kingdom's Secretary of State for Health and Social Care. He cited a loss of confidence in Prime Minister Keir Starmer's leadership after recent local elections.

The Labour Party's National Executive Committee has granted Andy Burnham permission to stand in the Makerfield by-election. His candidacy follows the resignation of the sitting MP, Josh Simons.

James Murray has been appointed as the new health secretary by Prime Minister Keir Starmer. The appointment follows Streeting's resignation and a period of internal party unrest.