The Belfast Wolves and Dublin Guardians are scheduled to play their opening match of the European T20 Premier League in Voorburg this Thursday.
David Miller, an International Cricket Council player known for his 35-ball century record, will feature prominently in the Belfast Wolves batting lineup alongside Devon Conway from New Zealand.
Chris Jordan forms a key part of the bowling attack for Belfast, having represented England at the World Cup and recorded more T20 wickets than any other bowler except Adil Rashid.
A significant number of players will hail from local backgrounds, with Mark Adair, Matthew Humphreys and Paul Stirling among those representing Ireland in one-day cricket.
The Irish contingent for Dublin includes Craig Young, Matthew Hollard, Josh Little, George Dockrell, Benjamin Calitz and Harry Tector.
Daryl Mitchell, who recently scored an unbeaten Test century against England at Trent Bridge in June, is expected to be a major drawcard for the Dublin squad.
Former Indian spinner Ravichandran Ashwin has also been linked with the Irish side.
Gavin Hoey, Tim Tector and Lorcan Tucker are set to join the local group, creating a scenario where some may find it unusual to compete against a team representing their own city.