Firefighters and paramedics attended an emergency call in the Sprucefield section of Hillsborough Road, Lisburn, following reports of a fall from height.
Two people were extracted from a building roof by rescue teams during operations that began around midday on Tuesday.
The specific location within the Sprucefield area was not detailed beyond the general Hillsborough Road vicinity where the incident occurred.
Medical professionals have not yet released information regarding the condition of the two individuals involved in the accident.
Local authorities and emergency services were contacted immediately after the event was reported to them.
The Northern Ireland Ambulance Service has been approached for further details on the casualties' health status.
No official statement confirming the cause or outcome of the incident has been issued by relevant bodies as of this time.