Firefighters are currently battling a fire inside a derelict building located at the Crumlin Road Courthouse site.
Police have closed both directions of traffic on Crumlin Road between Agnes Street and Carlisle Circus while emergency services work to control the blaze.
The structure involved is a listed building, and a cordon has been established on the pavement surrounding the property.
At least six fire appliances, including an aerial unit, along with three police vehicles have been dispatched to the scene in North Belfast.
The incident occurred near Mater Hospital, which officials confirm remains accessible to patients despite the disruption.
Five fire appliances and an aerial appliance were reported present at the location by local news outlets earlier this evening.
Emergency crews arrived following reports of a fire inside the derelict structure on Crumlin Road.
The Northern Ireland Fire and Rescue Service has been contacted for further details regarding the operation.
A section of the thoroughfare remains closed until the situation is fully resolved and safety can be assured.
No casualties have been reported in connection with the incident so far.