The Northern Ireland Executive has confirmed that major road works are set to begin on Friday 6 November at 7.00pm in Omagh.
A continuous one-way closure is scheduled for Mountjoy Street between Old Mountfield Road and Killybrack Road.
This restriction remains in effect until Sunday 8 November at 6.00pm.
During the shutdown, vehicles entering the town centre must follow a designated diversion route to exit.
The alternative path directs drivers through Sedan Avenue, McConnell Place, Abbey Street, Derry Road, Strathroy Road Link Road and U1528 Strathroy Road.
Resurfacing activities will cause further disruption on Saturday 21 November from 6.00am to 2.30pm.
A second closure window is planned for Sunday 22 November between the same hours.
The Department states that these measures are designed to ensure safety for both workers and road users.
It is expected that full two-way traffic will resume before the Christmas light switch-on event on Saturday 21 November.
Drivers are advised to allow additional travel time due to the temporary changes.